We have developed a high-performance data compression software with embedded data analysis features for radio-frequency (RF), multi-band images and video. It offers excellent compression ratios and quality levels with very small computing requirements which even allow for real-time operation on modest processors. Tests on OPS-SAT data reveal image ratios over 1:10 with excellent visual quality, and RF ratios over 1:3 with nearly identical spectrograms thanks to a smart lossy approach. Demanding and innovative applications are now possible in cubesats, including continuous optical or radio-frequency monitoring, maximizing the amount of useful information downlinked.