After prolonged interplanetary trips, the human neuron-muscular-skeletal system suffers severe deconditioning and impairment of the corresponding functions. In particular, the loss of neuron-sensory control and motor skills can be problematic and shall be counteracted efficiently. Integrated countermeasure systems shall be developed to allow astronauts being fit as soon as possible after landing (be it on earth or at their destination, e.g. Moon/Mars).